Blunted Expansion of Regulatory Tlymphocytes Is Associated With Increased Bacterial Translocation in Patients With Major Depressive Disorder

Major Depressive Disorder (MDD) is associated with both proinflammatory
and adaptive immune response abnormalities. Regulatory T lymphocytes (Tregs), a
subtype of CD4+ T cells, are relevant for maintaining immune-inflammatory system
homeostasis and control of inflammation such as the kind potentially induced by the
interactions between the intestinal microbiome and gut mucosa. We investigated the
Treg population and its distribution along their stages of differentiation/activation, as
well as its function in MDD patients without concomitant diseases. We also studied
the potential association between Treg alterations, intestinal barrier damage, and
bacterial translocation.

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